The laboratory currently have the capacity for multiple methods of drug analysis, including spectrophotometric assays, and HPLC-UV and UPLC-MS assays. One Applied Biosystems API3000 UPLC-MS/MS instrument and two Waters Xevo TQS UPLC-MS/MS instruments are housed in the Laboratory of Clinical Pharmacology. UPLC-MS/MS analysis provides the highest degree of sensitivity, selectivity and sample throughput. These instruments are dedicated to quantitation and identification of small molecules.
OROBOROS Oxygraph-2k. The modular system for high-resolution respirometry (HRR) in mitochondrial physiology and pathology.